Triamcinolone-H 3 was deposited primarily in the muscle, liver, intestine, skin, and kidney of the rat following intravenous administration. ![]() Triamcinolone exhibited the longest plasma half-life in the dog thus far reported for a corticosteroid. During the period of logarithmic fall in plasma triamcinolone concentration (22 to 480 minutes after injection), the half-life of triamcinolone was 116.7 ± 7.4 minutes the half-life of hydrocortisone measured by the same procedure was 54.3 ± 3.6 minutes. ![]() Triamcinolone was rapidly removed from dog blood after intravenous injection at 2 mg/kg not more than 15% of the dose could be extracted from total plasma 3 minutes after injection.
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